Research activities carried out in the Department are in connection with increasing efficiency and safety in the use of natural and synthetic substances and drugs with unclear toxicobiological characteristics and side effects, which is important problem in the processes of personal adaptation and social integration. The laboratories in the Department investigate biological activity of natural and synthetic substances, involvement of neuromodulatory mechanisms in their effects, as well as the possibilities of controlling and optimizing drug action. Oxidative stress (cell damage and protection from active forms of oxygen), the antioxidant activity of known and newly synthesized medicinal products aimed at protecting the cell from the harmful effects of free radicals are investigated; the role of proteosomes in liver damage due to oxidative stress, effects of known and newly synthesized drugs in neurodegenerative disorders are studied. Investigations are being conducted in the field of experimental drug toxicology, which contributes to clarifying the toxic effect of drugs and active forms of oxygen on cellular regulatory mechanisms.

  Period (2020-2022)